(‐)‐Epigallocatechin‐3‐gallate uncouples ATP‐sensitive K + channels from phosphatidylinositol polyphosphates and ATP
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The role of ATP-dependent K+ channels in antinociception, tolerance and morphine dependence
Tolerance and dependence are two main problems that have limited morphine administration as an analgesic drug and they might be as a result of changes in the number and affinity of receptors, dysfunction of adenylate cyclase, impaired coupling between activated µ receptor and K+ channels, and changes in the K+ and Ca2+ channels. There are several reports concerning the role of some of these...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.a957-d